Accordingly, we identified various epigenetic changes in ferroptosis-pyroptosis target genes in liver biopsies of late-stage MASLD/MASH patients, which could hold promise as novel stochastic biomarkers of lipid-related inflammatory liver damage (Figure 9; Supplementary Table S6), besides fibrosis stage (Sokolowska et al., 2022; Sun et al., 2022) or epigenetic clock age (Loomba et al., 2018; Li et al., 2022). The gene discussed is CLOCK; the disease is metabolic dysfunction-associated steatohepatitis.