PPARA and metabolic dysfunction-associated steatohepatitis: Furthermore, these results could also be confirmed in Epic Beadchip DNA methylation array data of MASLD liver biopsies of MASH patients (GSE241366) with advanced fibrosis in comparison to healthy tissue controls, which reveal similar enrichment of differentially methylated genes involved in lipid metabolism (fatty acid, bile acid) with PPARα as one of the top enriched TF motifs in general (Figure 6A) and especially of the hypermethylated genes (p-value < 0.05) (Figure 6B).