Of special note, in line with the fact that PPARα can also indirectly regulate genes via transrepression of other bound transcription factors such as NFκB (Delerive et al., 1999; Zúñiga et al., 2011; Tayyeb et al., 2020), we also observe multiple epigenetic changes of NFκB-driven (NFκB1, RelA, RelB) inflammatory target genes in the mouse/patient samples, which may further contribute to lipid-inflammation tissue damage in MASLD. Here, RELA is linked to metabolic dysfunction-associated steatotic liver disease.