Besides, new results identify hepatocyte pyroptosis and release of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome components as an additional mechanism to propagate liver injury and liver fibrosis development in MASH progression (Csak et al., 2011; Wree et al., 2014a; Beie et al., 2018; Wu et al., 2019). This evidence concerns the gene NLRP3 and Hepatic fibrosis.