Immunological characteristics specific of cancer stem cells (CSCs) such as the expression of tumor-associated antigens (TAAs), the secretion of cytokines and/or anti-apoptotic molecules along with the upregulation of STAT3 or PI3K/AKT survival signaling pathways, are able to increase resistance to apoptosis and inhibit immune response, facilitating tumor immune escape (Codony-Servat and Rosell, 2015). This evidence concerns the gene STAT3 and neoplasm.