EPHA4 and amyotrophic lateral sclerosis: Recently, synthetic EphA4 agonists were shown to prevent astrocyte-mediated motor neuron toxicity in astrocyte-motor neuron cocultures in both a SOD1-ALS and sALS context (Dennys et al., 2022), while mesenchymal stem cell-derived miRNA-containing extracellular vesicles as well as transfection with miRNA mimics could ameliorate the neurotoxic profile of ALS-astrocytes (Provenzano et al., 2022).