Neutralizing antibodies targeting TNF-α alleviated FUS-ALS astrocyte-induced motor neuron toxicity (Kia et al., 2018; Jensen et al., 2022), and activation of GLT-1 expression mediated through ß-lactam antibiotic administration in SOD1-mice resulted in delayed disease progression (Rothstein et al., 2005), although this later failed in a clinical trial. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.