Astrocyte involvement is not only evident in SOD1-ALS, as a recent study demonstrated how sALS patient induced pluripotent stem cell (iPSC)-derived astrocytes caused motor neuron degeneration, NMJ denervation and motoric deficits, when transplanted into the spinal cord of immune-deficient mice (Qian et al., 2017). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.