Recent findings suggest that axonal transport deficiencies are a common mechanism in ALS as impaired axonal transport of mitochondria, mRNA and endosomes in motor neurons harbouring mutations in FUS, TARDBP and C9orf72 has so far been demonstrated (Alami et al., 2014; Guo, et al., 2017a; Fazal et al., 2021; Fumagalli et al., 2021). Here, C9orf72 is linked to amyotrophic lateral sclerosis.