WWTR1 and cancer: Exercise-induced miRNAs are closely linked to the Hippo Tumor Suppressor Pathway, whose activation, through the inhibition of two homologous transcription factors, the Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ), block target genes, involved in cancer cell proliferation and survival (Badouel and McNeill, 2011; Yu et al., 2013).