Among the RibosomeR -identified tumor-associated RPs with an increased ratio, RPL5, RPL11, RPS3, RPS14, RPS19, RPS27, RPS27A, and RPS27L have been found to physically interact with MDM2 (Kang et al., 2021), which inhibits the function of the tumor suppressor p53 (Alarcon-Vargas and Ronai, 2002; Senturk and Manfredi, 2012). Here, RPS3 is linked to neoplasm.