Guimaraes and Zavolan analyzed The Cancer Genome Atlas (TCGA) data and found that certain ribosome protein (RP) genes, such as RPL39L, are commonly dysregulated in different cancer types; however, whether cancer cells and normal cells exhibit distinct ribosome heterogeneity remains unclear (Guimaraes and Zavolan, 2016). The gene discussed is BLOC1S3; the disease is cancer.