In astrocytes and glioblastoma cells RhoGDI1 interacts with the cytoplasmic domain of the β8 integrin subunit of the αvβ8 heterodimer, which limits the activity of Rac1 and Cdc42 (Reyes et al., 2013; Lee et al., 2015). This evidence concerns the gene RAC1 and glioblastoma.