As fragments of peptidoglycans represent strong pro-inflammatory molecules (Irazoki et al., 2019), the products of the combined activities of these enzymes (GH and peptidases) could also be an important factor contributing to inflammation, such as the damaging inflammations characteristic of both periodontitis (Baker et al., 2024) and trichomoniasis (Mercer and Johnson, 2018). The gene discussed is GH1; the disease is periodontitis.