Previous work in Parkinson’s disease (PD) patients have shown that motor cortex beta oscillations can be normalized with dopaminergic medication or basal ganglia deep brain stimulation.52 Given the shared alpha-synuclein pathology and basal ganglia/dopamine deficits between PD and DLB, this may explain why the Rolandic beta activity represented by Factor 3 is associated with disease severity in DLB but not ADem/AD-MCI and why Factor 3 may uniquely differentiate AD from DLB on machine learning classifiers (AUC = 0.61). The gene discussed is SNCA; the disease is Alzheimer disease.