Their findings unveiled reduced bone resorption and diminished pro-inflammatory cytokine levels in C57bl/6-10 mice compared to Balb/c mice, accompanied by heightened activation of the PI3K/Akt pathway and attenuated activation of the mTOR pathway in a ligature-induced periodontitis model (Laplante and Sabatini, 2012; Bi et al., 2023). Here, AKT1 is linked to periodontitis.