IFNG and periodontal disorder: Our study has yielded compelling insights into the divergent methylation patterns exhibited by the C57bl/6 and Balb/c mouse lineages, renowned for their disparate susceptibility to periodontal disease, C57bl/6 mice are characterized by a Th1-biased immune response, producing higher levels of pro-inflammatory cytokines such as IFN-γ, which is essential for cell-mediated immunity and the control of intracellular pathogens, often resulting in a more robust inflammatory response (Jankovic et al., 2001; Watanabe et al., 2004).