The former had been reported to be closely associated with the pathological status of diabetic db/db mice (Zhang et al., 2022), while the latter was well described as an equol-producing species that exerts lipid-lowering effects (Zheng et al., 2019), potentially serving as a compensatory mechanism for the metabolic disorders of ACE2 KO mice. The gene discussed is ACE2; the disease is Other metabolic disease.