Unlike the fecal metabolomics results of ACE2 KO mice, ACE2 overexpression significantly reduced the concentration of 2’-deoxyguanosine in HFD-fed mice, as well as the all-trans-13,14-dihydroretinol, a part of retinol metabolism, which was previously reported to be closely related to MetS in adults (Wei et al., 2023). Here, ACE2 is linked to metabolic syndrome.