IRS1 and fatty liver disease: Our previous research confirmed that ACE2 knockout mice showed a MetS-like state characterized by IR and hepatic steatosis, while ACE2 upregulation may reverse these effects by improving stress state, mitochondrial dysfunction, and insulin receptor substrate -1/protein kinase B/Adenosine 5’-monophosphate (AMP)-activated protein kinas, namely IRS-1/Akt/AMPK signaling (Song et al., 2021).