For instance, in PBC, MAIT cells accumulate in the liver through CXCL12-CXCR4 chemotaxis (57), while in IBD, chemokines like CCL20, CXCL10, CXCL16, and CCL25 might guide MAIT cells to the inflamed gut (58). Here, CXCR4 is linked to primary biliary cholangitis.