IL37 and inflammatory bowel disease: In IBD, activated macrophages produce increased levels of interleukin-12 and interleukin-23, and dendritic cells present antigens to naive T cells, facilitating the differentiation of T helper 1 (Th1) cells and T helper 17(Th17)cells, which produce proinflammatory cytokines, such as IFN-γ and tumor necrosis factor (TNF) (1).