For example, the complement factor cluster in HF cattle showed strong interactions between complement system proteins (C2, C3, C4A, CFB, CFH, C4BPA), LOC528040, MBL and TF in one cluster (Figure 4), whereas, in LF cattle, the complement cluster showed interactions between complement factors (CFB, CFH, C3, C4A, C4BPA, C8A, C8G), LOC528040 and SERPINA3-7 (Figure 5). This evidence concerns the gene C3 and hydrops fetalis.