Accordingly, CARTs secreted more IFN-γ, TNF-α, granzyme B and expressed more CD25, CD107a than blank-T cells when exposed to PDAC-CAFs, HCC-CAFs (Figures 3B–E) and PFs/breast cancer CAFs/colorectal cancer CAFs (Supplementary Figures 2B–E). Here, GZMB is linked to colorectal cancer.