Accumulation of several HexCer species in 50-week-old TAZ-KD hearts is consistent with previous findings from ischemic cardiomyopathy and the ageing heart, underlining the significance of HexCer accumulation in cardiomyopathy and ageing (Figure 6C) (Samouillan et al., 2020). The gene discussed is TAFAZZIN; the disease is ischemic cardiomyopathy.