Isolated CD4+ T cells from glioma-mice-lymph nodes have been shown to upregulate inhibitory molecules, such as CTLA-4 and PD-1, and decrease IL-2 production compared to CD4+ T cells isolated from engrafted tumors with LAMP-2AKO pericytes (Valdor et al., 2019). The gene discussed is CD4; the disease is central nervous system cancer.