PDCD1 and neoplasm: Moreover, the secretome of LAMP-2AKO pericytes reveals a decrease in inflammatory proteins such as gelsolin, periostin, and osteopontin, accompanied by an increase in anti-tumoral proteins such as lumican and vitamin D. CMA ablation in pericytes results in increased CD4+ T-cell activation with upregulation of PD-1 and CTLA-4, decreased Treg infiltration, and macrophage activation with the CD68 marker, suggesting an elicited immune response to hinder tumor cell growth (Figure 3, path 6) (Molina et al., 2022).