GBM microenvironment-M2-like macrophages have been demonstrated to promote pericyte recruitment and migration toward the extracellular adenosine deaminase protein CECR-1 via the PDGF-B–PDGFR-β axis downstream, stimulating periostin expression in pericytes with a proangiogenic activity on extracellular matrix components (Figure 2, path 7) (Zhu et al., 2017). This evidence concerns the gene PDGFRB and glioblastoma.