PDGFRB and cancer: Although PDGFR-β blockades prevent neo-vasculature formation in both PDGF-BB-positive and -negative tumors, they significantly inhibit metastasis formation by preventing pericyte loss and vascular permeability in high PDGF-BB-expressing tumors, but the same treatment leads to an increased number of cancer metastases in PDGF-BB-non-expressing tumors, thus suggesting that PDGF-BB levels in tumors might be potentially used as a marker to achieve personalized therapy (Hosaka et al., 2016).