Moreover, the secretome of LAMP-2AKO pericytes reveals a decrease in inflammatory proteins such as gelsolin, periostin, and osteopontin, accompanied by an increase in anti-tumoral proteins such as lumican and vitamin D. CMA ablation in pericytes results in increased CD4+ T-cell activation with upregulation of PD-1 and CTLA-4, decreased Treg infiltration, and macrophage activation with the CD68 marker, suggesting an elicited immune response to hinder tumor cell growth (Figure 3, path 6) (Molina et al., 2022). The gene discussed is CTLA4; the disease is neoplasm.