PIK3CA and Hepatic fibrosis: In the analysis of Yinchenhao decoction (YCHD), Cai et al. (2019) found that it has 45 active compounds and 296 potential targets, which showed an anti-liver fibrosis effect by regulating the PI3K-Akt signaling pathway and the TNF signaling pathway, and animal experiments confirmed that YCHD can effectively reduce the apoptosis of liver parenchymal cells and alleviate the symptoms of liver fibrosis.