Interestingly, we also found some AEs not mentioned in the instructions, which can have an effect on the respiratory system, including pulmonary oedema (n = 19), rales (n = 10); it can effect on the reproductive system and breast, including: gynaecomastia (n = 24), erectile dysfunction (n = 13); breast pain (n = 11); it may also affect the hepatobiliary system, including hepatic function abnormal (n = 11), alanine aminotransferase increased (n = 19), gamma-glutamyltransferase increased (n = 10). This evidence concerns the gene GPT and Gynecomastia.