CD8A and neoplasm: Overall, multiple metabolic pathways of immune cells like glycolysis and FAO in TME are designed for anti-tumor immune responses and pro-tumor immune escape, such as the deletion of M1 macrophages, N1 neutrophils, and CD8+T cells, and the activation of M2 macrophages, N2 neutrophils, and Treg cells (Xia Y. J. et al., 2021).