CD274 and hepatocellular carcinoma: In addition to alterations in these specific genes in metabolic reprogramming of HCC, Ally A’s study also identified other important targets such as Wnt signaling, mesenchymal-epithelial transition (Met), vascular endothelial growth factor A (VEGFA), telomerase reverse transcriptase (TERT), and the immune checkpoint proteins CTLA-4, PD-1, and PD-L1, which were regulated by anticancer agents.