Advances in high‐throughput sequencing techniques have revealed abnormal SERPINE1 expression in several cancers, including Colon cancer (CRC),8, 9, 10 GC,11 Pancreatic cancer (PAAD),12, 13, 14 Hepatocellular Carcinoma (HCC).15, 16. Here, SERPINE1 is linked to hepatocellular carcinoma.