Advances in high‐throughput sequencing techniques have revealed abnormal SERPINE1 expression in several cancers, including Colon cancer (CRC),8, 9, 10 GC,11 Pancreatic cancer (PAAD),12, 13, 14 Hepatocellular Carcinoma (HCC).15, 16. The gene discussed is SERPINE1; the disease is pancreatic adenocarcinoma.