Cell division cycle associated 8 (CDCA8) has been identified as a novel oncogene in HCC, which enhances tumor cell viability and DNA synthesis, promoting HCC progression and metastasis [86].Mutations in tumor suppressor genes TP53 and RB drive the evasion of anti-proliferative signals during HCC progression by regulating the cell cycle [87]. Here, TP53 is linked to hepatocellular carcinoma.