With the continuous production and accumulation of HCC cells, the liver microenvironment is eventually transformed into TME composed of immune cells (T cells, B cells, neutrophils, macrophages, DCs, NK cells, and MDSCs), cytokines (IL, TNF, TGF, interferon (IFN), and chemokines) and non-immune components (HSCs, carcinoma-associated fibroblasts (CAFs), ECM, metabolite, exosomes, and vasculature) [33–35]. This evidence concerns the gene TNF and hepatocellular carcinoma.