After completing immunogenic editing and developing the ability to hinder immune response, tumor cells can encourage immune cell depletion or differentiation into an immunosuppressive phenotype (Tregs, MDSCs, M2-TAMs, N2-TANs, CAFs) by releasing immune suppressive molecules (TGF-β, IL-10, VEGF, galectin, or IDO). The gene discussed is TGFB1; the disease is neoplasm.