Furthermore, findings of another study show that ATF3 can bind to and counteract common mutant p53 protein with the same affinity as that of its binding to the normal p53 protein and accordingly, it can reverse the drug resistance caused by p53 mutation and inhibit the migration of R175H-expressing SKBR3 and R273H-harbouring A431 cancer cell lines [10]. This evidence concerns the gene TP53 and cancer.