Using locally validated cut-off scores (Aβ42 < 680 pg/ml, Aβ42/40 < 0.055, Tau 400 X pg/ml, p(181)Tau > 62 pg/ml), almost all participants with AD-dementia showed abnormalities in Aβ40/42-ratio, compared to approximately 50% of all participants in the MCI-group and around 20% in the NC-group. Here, MAPT is linked to Alzheimer disease.