MMP14 and hepatocellular carcinoma: Next, the mutation status of prognostic genes and the incidence of CNVs in HCC were assessed; out of 371 HCC cases, 35 (9.43%) had mutations in metastasis- and BM-related genes, including ROBO1 (3%), ITGB5 (2%), ITGAM (1%), ITGA3 (1%), ITGAV (1%), ITGA2 (1%), and MMP14 (1%) (Fig. 2E).