In addition, upregulation of COL4A1, a gene encoding collagen IV, promotes the proliferation and metastasis of HCC cells via FAK-Src signaling [9], and overexpression of LAMC1 and LAMA4, genes encoding subunits of laminin, predicts poor prognosis and enhances HCC cell invasion and migration [10, 11]. Here, COL4A1 is linked to hepatocellular carcinoma.