Genetic counselling is already recommended for patients with somatic EGFR positive NSCLC younger than 50 years, regardless of their family history [10], however, a proper syndromic EGFR-associated lung cancer should be suspected in the case of the novo EGFR T790M mutations, especially with a somatic variant allele frequency (VAF) ≥ 35% [10, 72], with even more rare EGFR variants, such as V834L and V843I being increasingly recognized [73, 74]. This evidence concerns the gene EGFR and lung cancer.