Previously, to explore the efficacy of anti-PD-L1 treatment in GBM, we employed a sleeping beauty (SB) transposon orthotopic xenograft-bearing murine model treated with anti-PD-L1 therapy, which revealed that anti-PD-L1 monotherapy had no significant inhibition on GBM growth [12]. The gene discussed is CD274; the disease is glioblastoma.