Then, we performed Pearson correlation analysis between 67 IC genes and IFN signaling activation score (type I and type II, respectively) among RNA sequencing (RNA-seq) data from clinical GBM samples (CMU cohort, n = 208) and two public independent GBM transcriptomic datasets (The Cancer Genome Atlas, TCGA n = 168, and Chinese Glioma Genome Atlas, CGGA n = 144) (Table S5). This evidence concerns the gene IFNA1 and central nervous system cancer.