After intersecting the top 15 ICs which expression was most positively associated with IFN type I and type II score in these three GBM RNA-seq datasets, CD86, CD48, TIM-3, TNFRSF14 and TNFRSF1B were disclosed as five overlapping genes strongly related to IFN signaling (Fig. 1A, Figure S1A-C and Table S6). The gene discussed is HAVCR2; the disease is glioblastoma.