Altogether, these results suggest CXCL1 and CXCL5 are two major cytokines regulating GBM cell intrinsic TNFRSF14-induced macrophage phenotype transition, and these two cytokines are regulated by TNFRSF14/FAK/NF-κB axis in GBM cells. The gene discussed is PTK2; the disease is glioblastoma.