Additionally, enhanced IFN-γ expression accompanied with TNFRSF14 elevation (High-IFNG & High-TNFRSF14) indicated a shorter survival in glioma than the lower counterpart (Low-IFNG & Low-TNFRSF14), while similar results couldn’t be obtained from PD-L1 (Fig. 1N and Figure S1H). Here, IFNG is linked to central nervous system cancer.