Secondly, we did not include the variants HLA-B*57:01:01, rs2032582 (ABCB1), rs1799931 (NAT2), rs717620 (ABCC2) and rs10946737 (RIPOR2) (www.PharmGKB.org), with allele frequencies below 10%, despite their strong association with HIV- or TB treatment-induced DIH/ADRs, due to technical limitations in constructing the SNP genotyping panel, and selected variants had allele frequencies > 10% known to occur in African populations. This evidence concerns the gene RIPOR2 and tuberculosis.