Subsequently, among 23 pharmacogenetic variants in genes CYP2A6, CYP2B6, CYP3A4, CYP3A5, UGT2B7, NAT2, ABCB1, SLC01B1, NF-κB1, TNF-α, CUX2 and AGBL4, we found the non-ADME variant rs4647992 (NF-kB1) minor allele T associated with DIH in HIV/TB patients (p = 0.032) (Supplementary Table 3). The gene discussed is CYP3A5; the disease is tuberculosis.