Activation of STAT3 is involved in the polarization of M2 macrophages (Degboe et al., 2019; Ma et al., 2019; Wen et al., 2018), and promotes tumor development (Degboe et al., 2019; Ye et al., 2019; Zhang, Li, et al., 2019), and the research of the effect of STAT3 on macrophage polarization has obtained attention in recent years (Xiong et al., 2012). The gene discussed is STAT3; the disease is neoplasm.