Mitochondrial-related genes, MT-CO1, MT-ATP6, and MT-CO3, are known to be associated with cell aging and apoptosis, so we focused on NEAT1. Compared to primary cancer cells, NEAT1 upregulated after metastasis and further increased in neoBM, suggesting NEAT1 may play a more central role in brain metastasis (Fig. 3I). This evidence concerns the gene NEAT1 and cancer.