To further investigate the impact of IMPDH2 on hepatoblastoma (HB) proliferation in vivo, HepG2 and Huh6 cells were transfected with stable short hairpin negative control (shNC) and short hairpin IMPDH2 (shIMPDH2) constructs, specifically shIM#1 and shIM#2. Here, IMPDH2 is linked to hepatoblastoma.