HMGA2 and serous adenocarcinoma: Also in ovarian tissue, overexpression of HMGA2 in normal ovarian epithelial cells has been associated with malignant transformation, as HMGA2 exhibited increased overexpression in Serous Tubal Intraepithelial Carcinoma (STIC) lesions, suggesting an early event in the formation of high-grade serous carcinomas [59].