Upregulated in CML patients, particularly those in the acute phase, YBX1 cooperates with IGF2BP protein in CML cell lines to regulate the m6A-dependent stability of YWHAZ mRNA, an activator of the PI3K/AKT/mTOR signaling pathway. The gene discussed is YWHAZ; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.