DLG4 and Alzheimer disease: In addition, it is known that beta-Amyloid co-localizes with PSD-95 specifically at excitatory synapses in human post-mortem AD brains as well as in cultured murine neurons exposed to beta-Amyloid oligomers (Lacor et al, 2004) where it might induce the degradation of PSD-95 specifically by proteasomes (Roselli et al, 2005).