Obesity and hypogonadism in BBS1 are less frequent than in patients with BBS2 or BBS10. They also present lower levels of insulin resistance (lower HOMA-IR) and lower visceral adiposity than BBS10 patients, who have a trend toward increased insulin resistance (higher HOMA-IR) and increased triglycerides. The gene discussed is BBS10; the disease is obesity due to melanocortin 4 receptor deficiency.