A global trend is to consider relatively milder phenotype for patients with BBS1 variants, compared with variants in the chaperonin-like genes namely BBS6, BBS10, BBS12 [16], as described in a study focusing on the retinal dystrophy [17] or a number of studies focusing on the kidney manifestations and confirmed by a recent meta-analysis [18]. The gene discussed is BBS12; the disease is Retinal dystrophy.