Additionally, there is emerging data that SGLT2is may also be beneficial in type 1 diabetes.38,39 Fourth, we lacked reliable data on additional comorbidities (i.e., heart failure, chronic kidney disease, or strokes), laboratory measures (i.e., glucose, hemoglobin A1c, creatinine, microalbuminuria), and medications (i.e., insulin) that signify greater cardiovascular risk or worse diabetes control. The gene discussed is INS; the disease is heart failure.