In this paper, we used a prospective cohort with a follow-up period of 18 months to investigate the association between the baseline levels of the inflammatory markers TNF-α and IL-1ß and of endothelial cell markers VCAM-1, ICAM-1, and E-selectin and the rate of cognitive decline in patients with mild-to-moderate AD. This evidence concerns the gene ICAM1 and Mental deterioration.