E2F5 and posterior cortical atrophy: To investigate prognostic implications in PCa, we selected five out of the 27 candidate genes (STX3, CABLES2, E2F5, RALA, POLE3) utilizing univariate Cox and LASSO Cox regression analyses (p < 0.05) to build a prognostic risk model (Fig. 6A-B, Supplementary Table 5).