Based on this scientific background, we conducted a phase II study to formally evaluate whether talazoparib achieves clinical benefit (complete response (CR), partial response (PR) or stable disease (SD) ≥ 24 weeks) in metastatic or inoperable locally advanced or locally recurrent cancer patients who have germline mutations in BRCA1 or BRCA2 with cancers other than breast or ovarian cancer, PTEN mutation/deletion or loss by IHC and in patients with somatic mutations or homologous deletions in BRCA1 or BRCA2, or alterations in other HR repair pathway genes. The gene discussed is BRCA2; the disease is ovarian carcinoma.