As shown in Fig. 2A, knockdown of ESRRG markedly inhibited the growth of SCLC cells, resulting in poor survival of the cells as measured by colony formation and causing pronounced apoptosis, reflected by the activation of caspase3/7 and cleaved PARP1 (Fig. 2B–D; Appendix Fig. S2A–C). This evidence concerns the gene PARP1 and small cell lung carcinoma.