Recently, improved molecular understanding has brought new promising opportunities for SCLC treatment, and several inhibitors targeting MYC (Mollaoglu et al, 2017), DLL3 (Jaspers et al, 2023), EZH2 (Gardner et al, 2017), LSD1 (Chen et al, 2022a) and CDK7 (Zhang et al, 2020) have entered clinical trials. The gene discussed is DLL3; the disease is small cell lung carcinoma.