Subsequent ChIP-seq analysis using a tRCC cell line (UOK146) demonstrated that TFE3 binds to the PPARGC1A promoter to upregulate DEGs more often than to downregulate DEGs (Fig. 3d, e). The gene discussed is TFE3; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.