Similar results were observed in apilimod-treated cells (Fig. 5d, bottom panels and Supplementary Fig. 13e), as indicated in a recent report suggesting that inhibition of PIKfyve kinase not only induced abnormal enlargement and vacuolization of EEA1-positive endosomes with pseudotyped Ebolavirus but also blocked SARS-CoV-2 infection20. Here, EEA1 is linked to severe acute respiratory syndrome.