ELN and metabolic disease: Concurrently, since ELNs are essential for the regulation of metabolism through the classification and distribution of signaling receptors and membrane transporters of hormones or metabolites such as the insulin/glucagon receptor, glucose transporter 4, glucagon-like peptide-1 receptor, and low-density lipoprotein receptor7, ELN dysfunction is considered an important mechanism in the pathogenesis of metabolic diseases.