MCCC2 and obesity due to melanocortin 4 receptor deficiency: Among them is Dynamin-1-like protein (DNM1L, DNM1L gene), crucial for mitochondrial and peroxisomal division, and Methylcrotonoyl-CoA carboxylase beta chain (MCCB, MCCC2 gene), which is essential for leucine catabolism30, linked with obesity and insulin resistance72.