Notably, both HLA-I-specific and HLA-II-specific pGenes included known drug targets for autoimmune diseases, infectious diseases, and cancer such as LAG3, PDCD1, TNF, and ACE2 affected by HLA-I; and IL18, TREM2, VSIG4, and TLR1 by HLA-II. This evidence concerns the gene TREM2 and autoimmune disease.