During the follow-up period, insulin (t73 = 3.705, p = 0.0004, estimate = 9.97, 95% CI [4.6, 15.3], ES (Cohen’s d) = 2.5, ES 95% CI [1.1, 3.9],) and insulin resistance (t73 = 3.539, p = 0.0007, estimate = 1.205, 95% CI [0.5, 1.9], ES (Cohen’s d) = 2.4, ES 95% CI [1.0, 3.8],) levels significantly increased in CHR-C, but not in CHR-NC (Fig. 4). This evidence concerns the gene INS and Insulin resistance.