INS and Insulin resistance: When we compared the difference of the change of insulin and insulin resistance between groups, we found that the increase in fasting insulin and insulin resistance was significantly different in CHR compared to CTR (insulin: Group by time t74 = 3.119, p = 0.003; insulin resistance: Group by time t74 = 2.970, p = 0.004), and in CHR compared to FEP (insulin: Group by time t74 = 2.447, p = 0.016; Group by time t74 = 2.380, p = 0.020) but not in FEP compared to CTR.