INS and Insulin resistance: There was a statistically significant increase in insulin (t74 = 3.334, p = 0.0013, estimate = 4.49, 95% CI [1.8, 7.2], ES (Cohen’s d) = 1.12, ES 95% CI [0.4, 1.8],) and insulin resistance (t74 = 3.232, p = 0.0018, estimate = 0.549, 95% CI [0.2, 0.9], ES (Cohen’s d) = 1.08, ES 95% CI [0.4,1.8]) levels in CHR, but not in FEP or CTR during the follow-up period.