PARP1 and necrotizing enterocolitis: Of note, compared to the wild-type mice, NEC-induced intestinal epithelial damage in Parp1-deficient mice was substantially ameliorated, as evidenced by a relatively intact villus morphology without obvious disorder in intestinal villus arrangement and breakage, with significantly reduced intestinal histopathological severity scores (Fig. 5B, C) as well as markedly attenuated epithelial cell death (Fig. 5D, E).