To explore the function of NAT10 in the chemoresistance in HCC, we generated oxaliplatin-resistant Huh7 (Huh7-OXA-R) cells and found that NAT10 expression was upregulated in Huh7-OXA-R cells compared with the parental cells (Fig. 1C). Here, NAT10 is linked to hepatocellular carcinoma.