To test a direct role for MYC/MYCN in BI-2536 sensitivity, we selected SCLC cell lines with high MYC expression (H82, H446, and DMS273), high MYCN expression (H69), and low MYC expression (SHP77) to assess whether MYC/MYCN depletion confers BI-2536 resistance. The gene discussed is MYC; the disease is small cell lung carcinoma.