A previous study in patients with CV diseases comparing SPC with MPC demonstrated a reduction in CV events in favour of SPC.23 An analysis with renin-angiotensin system inhibitor combinations given as a single pill or multiple pills confirmed this observation in patients with hypertension.21 In the retrospective, observational NEPTUNO study using data from electronic-health records, patients were distributed into four different cohorts: a single pill containing ASA/atorvastatin/ramipril (case cohort), identical mono components taken separately. Here, REN is linked to Hypertension.