A trend for a lower ratio of higher apparent molecular weight TMCC2 to lower apparent molecular weight TMCC2 was observed between APOE3 homozygous controls versus APOE3 homozygous AD cases, but did not meet the commonly accepted threshold for statistical significance of p = 0.05 (Student's t‐test p = 0.07 and p = 0.13 for temporal gyrus and cerebellum, respectively). Here, TMCC2 is linked to Alzheimer disease.