In non‐demented controls and age‐matched late onset AD cases stratified by APOE genotype, we found an association of APOE genotype and/or dementia with variation in the apparent molecular weight of TMCC2 as assessed by SDS–PAGE (Figure 5), all TMCC2 bands migrated at or above the expected position for the full‐length 709‐amino acid protein, and thus may reflect differential post‐translational modification of TMCC2, though alterations in mRNA splicing cannot be excluded. Here, APOE is linked to dementia.