APP and Alzheimer disease: In late onset AD brains from both APOE3 and APOE4 homozygotes, neurons had a shrunken appearance, with the distribution of TMCC2 immunoreactivity being similar to that seen in age‐matched non‐demented controls, though we subjectively noted a trend towards an increase of APP staining that was not co‐incident with that for TMCC2 (Figure 2A,B) that was reflected in a trend for a reduced co‐localization of APP and TMCC2 immunoreactivity, which however did not reach the conventional threshold for statistical significance, potentially caused by the small sample size (Figure S2C).