In late onset AD brains from both APOE3 and APOE4 homozygotes, neurons had a shrunken appearance, with the distribution of TMCC2 immunoreactivity being similar to that seen in age‐matched non‐demented controls, though we subjectively noted a trend towards an increase of APP staining that was not co‐incident with that for TMCC2 (Figure 2A,B) that was reflected in a trend for a reduced co‐localization of APP and TMCC2 immunoreactivity, which however did not reach the conventional threshold for statistical significance, potentially caused by the small sample size (Figure S2C). Here, TMCC2 is linked to Alzheimer disease.